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After surgery I was pronounced cancer free but still put in Aromasin. I found the side effects difficult especially insomnia. My schedule is busy and this plus muscle/joint pain is hard. I went off for several months during a vacation and felt far better. I returned to taking it and almost immediately the side effects returned. I have very mixed feelings about continuing. My health insurance covers it so thankfully expense is not an issue. I will probably continue as statistically the drug has proved valuable.

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Lonning PE, Bajetta E, Murray R, Tubiana-Hulin M, Eisenberg PD, Mickiewicz E, Celio L, Pitt P, Mita M, Aaronson NK, Fowst C, Arkhipov A, di Salle E, Polli A, Massimini G 2000 Activity of exemestane in metastatic breast cancer after failure of non steroidal aromatase inhibitors: a phase II trial.

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Did not need chemo based on the Oncotype 2 test (chemo would have made no difference in 10 yr recurrence).

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Prescription pain medicines may be one of the biggest reasons people with cancer experience constipation.

Other aromatase inhibitors, such as the first-generation aminoglutethimide, have limited use due to toxicity and lack of selectivity for the aromatase enzyme, necessitating concomitant corticosteroid supplementation in some cases.

There is also a decent amount of preclinical data suggesting that Aromasin has a beneficial effect on bone mineral metabolism that is not seen with non-steroidal agents, and it may also have beneficial effects on lipid metabolism that are not found in the non-steroidal letro and A-dex.

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The frequency of metastatic brain tumors is thought to be rising because of prolonged survival after primary cancer is diagnosed; this change is a direct result of improvements in early detection and effective treatments.

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