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After surgery I was pronounced cancer free but still put in Aromasin. I found the side effects difficult especially insomnia. My schedule is busy and this plus muscle/joint pain is hard. I went off for several months during a vacation and felt far better. I returned to taking it and almost immediately the side effects returned. I have very mixed feelings about continuing. My health insurance covers it so thankfully expense is not an issue. I will probably continue as statistically the drug has proved valuable.
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Lonning PE, Bajetta E, Murray R, Tubiana-Hulin M, Eisenberg PD, Mickiewicz E, Celio L, Pitt P, Mita M, Aaronson NK, Fowst C, Arkhipov A, di Salle E, Polli A, Massimini G 2000 Activity of exemestane in metastatic breast cancer after failure of non steroidal aromatase inhibitors: a phase II trial.
This research will inform us on the safety of exemestane for breast cancer prevention.
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Approximately 33% of patients, and nearly 50% of patients in this group are not surgical candidates because of inaccessibility of the tumor, extensive systemic disease, and other factors.
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Did not need chemo based on the Oncotype 2 test (chemo would have made no difference in 10 yr recurrence).
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Benign tumors are not cancer, and doctors can usually remove them.
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ITT patients enrolled received enzalutamide as their first- or second-line treatment and median PFS on enzalutamide in diagnostic positive patients was 40.
Prescription pain medicines may be one of the biggest reasons people with cancer experience constipation.
Other aromatase inhibitors, such as the first-generation aminoglutethimide, have limited use due to toxicity and lack of selectivity for the aromatase enzyme, necessitating concomitant corticosteroid supplementation in some cases.
There is also a decent amount of preclinical data suggesting that Aromasin has a beneficial effect on bone mineral metabolism that is not seen with non-steroidal agents, and it may also have beneficial effects on lipid metabolism that are not found in the non-steroidal letro and A-dex.
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Metastatic breast cancer is treatable but it is not curable.
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Aromasin not only increases testosterone and lowers estrogen, but it also increases levels of insulin -like growth Factor (IGF).
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The 5-year rate of freedom from recurrence at a distant site was 93.
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The frequency of metastatic brain tumors is thought to be rising because of prolonged survival after primary cancer is diagnosed; this change is a direct result of improvements in early detection and effective treatments.
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